Calcium signals and reactive oxygen species in PDGF-BB, VEGF and FGF-2 mediated vasculogenesis of embryonic stem cells

Calcium signals and reactive oxygen species in PDGF-BB, VEGF and FGF-2 mediated vasculogenesis of embryonic stem cells

Our group is investigating signaling pathways of cardiovascular differentiation of embryonic stem cells of mouse and human origin. In the current research project the interaction of intracellular calcium and reactive oxygen species during vasculogenesis of stem cells will be assessed. We will investigate the cooperation of pro-angiogenic growth factors, e.g. VEGF, PDGF-BB and FGF-2 in blood vessel differentiation and the impact of oxygen radicals and intracellular calcium changes in this process. We are seeking a highly motivated student who is enthousiastic for stem cell biology and wants to integrate into an internationally oriented research group. The current research project is a subproject of the international graduate college “Signalling Mechanisms in Lung Physiology and Disease” (SMLPD) (see: http://uglc.de/education/smldp). The duration of the research project is 3 years and is funded according to the regulations of the German Research Foundation for Graduate Colleges. The scholarship offers the opportunity for a research stay at the Northwestern University in Chicago.

Homepage : http://www.ugcvr.com

Category : Biology, Developmental Biology, Stem Cell Biology

Contact address : Prof. Dr. Heinrich Sauer, Department of Physiology, Justus Liebig University Giessen, Aulweg 129, 35392 Giessen, Germany Email: heinrichsauer@netscape.net

Keywords : stem cells, cardiovascular differentiation